Connecting dots at the interface of biology and biomedical engineering
Welcome to JT lab
- The isolation of UHMWPE, metal and ceramic particles from different implants and study the biological responses to wear debris contributing to the understanding of implant failure and the development of longer lasting, more reliable medical devices and implants.
- Isolation, characterisation and determination of the cellular responses to wear particles from new and novel material.
- Investigation of spinal cord cellular responses to wear products from spinal implants and instrumentation alongside projects investigating neural stem cell and primary neural cell responses to matrix stiffness of novel hydrogel scaffolds for central nervous system repair.
- Spinal cord injury and repair.
- Mechanobiology and understanding the structure-function relationship in the intervertebral disc (IVD) tissue at the multi-scale (macro, micro, and nano), leading to the development of bio-inspired scaffolds.
- Development of 3D IVD organ models (3D bioprinting and IVD-on-a-chip) for low back pain studies.
Developing such a deep understanding will effectively assist us to translate our research into clinical applications through fabricating functional implants with particular focus on the intervertebral disc, spinal cord, and articular cartilage. In the spirit of our research program, we develop novel fluorescent biosensors, based on aggregation-induced emission materials, to tackle major research projects in modern biomedical science.
We work closely with our collaborators to fabricate bioinspired tissue-engineered scaffolds based on novel hybrid hydrogels using the state-of-the-art facilities (3D printing and bioprinting, vortex Fluidic Device, etc.).